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Article

Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus.

Infection and immunity - 1 May 2010

Geiger Tobias, Goerke Christiane, Fritz Michaela, Schäfer Tina, Ohlsen Knut, Liebeke Manuel, Lalk Michael, Wolz Christiane

Abstract excerpt

In most bacteria, nutrient limitations provoke the stringent control through the rapid synthesis of the alarmones pppGpp and ppGpp. Little is known about the stringent control in the human pathogen Staphylococcus aureus, partly due to the essentiality of the major (p)ppGpp synthase/hydrolase enzyme RSH (RelA/SpoT homolog). Here, we show that mutants defective only in the synthase domain of RSH (rsh(syn)) are not...

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Identifiers

PMID: 20212088
DOI: 10.1128/IAI.01439-09
PMCID: PMC2863498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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