Article
RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity.
Frontiers in cellular and infection microbiology - 1 Jan 2017
Abdou Elias, Jiménez de Bagüés María P, Martínez-Abadía Ignacio, Ouahrani-Bettache Safia, Pantesco Véronique, Occhialini Alessandra, Al Dahouk Sascha, Köhler Stephan, Jubier-Maurin Véronique
Abstract excerpt
For aerobic human pathogens, adaptation to hypoxia is a critical factor for the establishment of persistent infections, as oxygen availability is low inside the host. The two-component system RegB/A of Brucella suis plays a central role in the control of respiratory systems adapted to oxygen deficiency, and in persistence in vivo. Using an original "in vitro model of persistence" consisting in gradual oxygen...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.