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Article

The stringent response and <i>Mycobacterium tuberculosis</i> pathogenesis

8 Jun 2018

Abstract excerpt

During infection, the host restrains Mycobacterium tuberculosis (Mtb) from proliferating by imposing an arsenal of stresses. Despite this onslaught of attacks, Mtb is able to persist for the lifetime of the host, indicating that this pathogen has substantial molecular mechanisms to resist host-inflicted damage. The stringent response is a conserved global stress response in bacteria that involves the production...

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PMID: 29947752
DOI: 10.1093/femspd/fty054

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