Article
Complexity and diversity of hepatitis B virus quasispecies: correlation with long-term entecavir antiviral efficacy.
Antiviral research - 1 Sept 2013
Tong Jin, Li Qing-Ling, Huang Ai-Long, Guo Jin-Jun
Abstract excerpt
This study was undertaken to determine the complexity and diversity of hepatitis B virus (HBV) quasispecies during long-term antiviral therapy and examine their impacts on therapeutic outcome. Six chronic hepatitis B patients receiving entecavir monotherapy (0.5mg/day) for 3 years were enrolled. The reverse transcriptase region of the HBV polymerase gene was sequenced and HBV quasispecies complexity and diversity...
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