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Article

Evolutionary patterns of hepatitis B virus quasispecies under different selective pressures: correlation with antiviral efficacy.

Gut - 1 Sept 2011

Liu Feng, Chen Li, Yu De-Min, Deng Lin, Chen Rong, Jiang Yin, Chen Liang, Huang Su-Yuan, Yu Jia-Lun, Gong Qi-Ming, Zhang Xin-Xin

Abstract excerpt

OBJECTIVE: To investigate the evolution of hepatitis B virus (HBV) quasispecies (QS) within the reverse transcriptase (RT) region during the early stage of entecavir treatment and its impact on virological response, and to compare evolutionary patterns under different selective pressures. METHODS: 31 patients with chronic hepatitis B receiving entecavir (17 responders and 14 partial responders according to the...

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Identifiers

PMID: 21292683
DOI: 10.1136/gut.2010.226225

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