Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the genetic interaction between ERAP1/ERAP2 and HLA-B*52:01 in Takayasu arteritis.

Rheumatology (Oxford, England) - 8 Jan 2026

Casares-Marfil Desiré, Saruhan-Direskeneli Güher, Grayson Peter C, Tombetti Enrico, Jiang Lindi, Merkel Peter A, Direskeneli Haner, Sawalha Amr H

Abstract excerpt

OBJECTIVES: Takayasu arteritis is a rare vasculitis characterized by inflammation of large arteries. Given the robust genetic association with HLA-B*52:01, it was recently proposed to classify Takayasu arteritis within the spectrum of MHC-I-opathies. Although genetic associations in ERAP1 and ERAP2 have been described in several MHC-I-opathies, their role in Takayasu arteritis remains unclear. This study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopeptidases
Share to ERAP1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Minor Histocompatibility Antigens

Share to Polymorphism, Single Nucleotide

Share to Takayasu Arteritis

Source

Open in PubMed Open full text

Identifiers

PMID: 41100049
DOI: 10.1093/rheumatology/keaf544
PMCID: PMC13396782

Genes

ERAP1
ERAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the genetic interaction between ERAP1/ERAP2 and HLA-B*52:01 in Takayasu arteritis.PMID 41100049Read ↗

Identification of multiple genetic susceptibility loci in Takayasu arteritis.Semantic proximity Read ↗

Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study.Semantic proximity Read ↗

The genetics of Takayasu arteritis.Semantic proximity Read ↗

Revisited HLA and non-HLA genetics of Takayasu arteritis--where are we?Semantic proximity Read ↗

Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population.Semantic proximity Read ↗

Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritisSemantic proximity Read ↗

The Severity of Takayasu Arteritis Is Associated with the HLA-B52 Allele in Japanese Patients.Semantic proximity Read ↗

Association of Takayasu arteritis with HLA-B 67:01 and two amino acids in HLA-B protein.Semantic proximity Read ↗

New human leukocyte antigen risk allele in Japanese patients with Takayasu arteritis.Semantic proximity Read ↗

Comprehensive Analysis of the HLA Class I and the HLA Class II Alleles in Patients with Takayasu Arteritis: Relationship with Clinical Patterns and PrognosisSemantic proximity Read ↗

Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.Semantic proximity Read ↗

Angiogenesis related genes in Takayasu Arteritis (TAK): robust association with Tag SNPs of IL-18 and FGF-2 in a South Asian Cohort.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.