Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis

Abstract excerpt

Significance Takayasu arteritis (TAK) is a systemic vasculitis with unknown etiology. We identified four unreported susceptibility genes to TAK through genome-wide association studies. We successfully fine-mapped HLA associations and showed that HLA-G is associated with TAK in addition to HLA-B*52. The association between PTK2B and TAK could be explained by expression regulation of PTK2B. We showed an epistasis...

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