Article
Genetic variability in copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with Alzheimer's disease in a Chinese population.
Journal of biological regulators and homeostatic agents - 1 Jan 2000
Liu H P, Lin W Y, Wang W F, Tsai C H, Wu W C, Chiou M T, Shen C P, Wu B T, Tsai F J
Abstract excerpt
Previous experiments demonstrated that transgenic mice carrying both amyloid precursor protein and mutant ATP7B transgenes reduce amyloid plaques and diminish plasma Abeta levels. These experiments showed that a structural change of ATP7B may affect Alzheimers disease (AD) susceptibility. In this study three missense SNPs in ATP7B gene (rs1801243, rs1801244, and rs1801249) were chosen to test whether they were...
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