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Article

ATP7B variants as modulators of copper dyshomeostasis in Alzheimer's disease.

Neuromolecular medicine - 1 Sept 2013

Squitti Rosanna, Polimanti Renato, Siotto Mariacristina, Bucossi Serena, Ventriglia Mariacarla, Mariani Stefania, Vernieri Fabrizio, Scrascia Federica, Trotta Laura, Rossini Paolo Maria

Abstract excerpt

To understand the role of the key copper-regulating gene, ATP7B, in copper dyshomeostasis associated with Alzheimer's disease (AD), we analyzed the serum levels of copper, ceruloplasmin and 'free' (i.e., non-ceruloplasmin bound) copper in 399 patients with AD and 303 elderly healthy controls. We also performed analyses of informative variants of ATP7B. AD patients had higher levels of copper and free copper than...

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PMID: 23760784
DOI: 10.1007/s12017-013-8237-y

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