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Article

Linkage disequilibrium and haplotype analysis of the ATP7B gene in Alzheimer's disease.

Rejuvenation research - 1 Feb 2013

Squitti Rosanna, Polimanti Renato, Bucossi Serena, Ventriglia Mariacarla, Mariani Stefania, Manfellotto Dario, Vernieri Fabrizio, Cassetta Emanuele, Ursini Francesca, Rossini Paolo Maria

Abstract excerpt

Copper dyshomeostasis leading to a labile Cu(2+) not bound to ceruloplasmin ("free" copper) may influence Alzheimer's disease (AD) onset or progression. To investigate this hypothesis, we investigated ATP7B, the gene that controls copper excretion through the bile and concentrations of free copper in systemic circulation. Our study analyzed informative ATP7B single-nucleotide polymorphisms (SNPs) in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22950421
DOI: 10.1089/rej.2012.1357
PMCID: PMC3582274

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