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Article

Association between the c. 2495 A>G ATP7B Polymorphism and Sporadic Alzheimer′s Disease

1 Jan 2011

Abstract excerpt

Nonceruloplasmin-bound copper ("free") is reported to be elevated in Alzheimer's disease (AD). In Wilson's disease (WD) Cu-ATPase 7B protein tightly controls free copper body levels. To explore whether the ATP7B gene harbours susceptibility loci for AD, we screened 180 AD chromosomes for sequence changes in exons 2, 5, 8, 10, 14, and 16, where most of the Mediterranean WD-causing mutations lie. No WD mutation,...

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PMID: 21760992
DOI: 10.4061/2011/973692

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