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Article

A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.

Immunity - 23 Nov 2011

Siegel Andrea M, Heimall Jennifer, Freeman Alexandra F, Hsu Amy P, Brittain Erica, Brenchley Jason M, Douek Daniel C, Fahle Gary H, Cohen Jeffrey I, Holland Steven M, Milner Joshua D

Abstract excerpt

STAT3 transcription factor signaling in specific T helper cell differentiation has been well described, although the broader roles for STAT3 in lymphocyte memory are less clear. Patients with autosomal-dominant hyper-IgE syndrome (AD-HIES) carry dominant-negative STAT3 mutations and are susceptible to a variety of bacterial and fungal infections. We found that AD-HIES patients have a cell-intrinsic defect in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22118528
DOI: 10.1016/j.immuni.2011.09.016
PMCID: PMC3228524

Genes

STAT3
BCL6
SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.PMID 22118528Read ↗

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