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Article

Genetic polymorphisms predicting methotrexate blood levels and toxicity in adult non-Hodgkin lymphoma.

Leukemia & lymphoma - 1 Mar 2014

Avivi Irit, Zuckerman Tsila, Krivoy Norberto, Efrati Edna

Abstract excerpt

Methotrexate (MTX), a folate antagonist employed for treating a wide range of malignancies, has an extensive interpatient variability, resulting in unpredictable toxicity. The present study evaluated the impact of single gene polymorphisms (SNPs: rs1801133 and rs1801131 in the MTHFR gene; rs4149056 and rs11045879 in the SLC01B1 gene; and rs2032582 and in the ABCB1 transporter gene) on MTX blood levels...

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Share to Aged, 80 and over
Share to Antimetabolites, Antineoplastic
Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Lymphoma, Non-Hodgkin
Share to Methotrexate
Share to Methylenetetrahydrofolate Reductase (NADPH2)
Share to Neoplasm Staging

Source

Identifiers

PMID: 23829278
DOI: 10.3109/10428194.2013.789506

Genes

ABCB1
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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