Influence of FPGS rs1544105 and GGH rs3758149 Gene Polymorphisms on Methotrexate Pharmacogenetics.

doi:10.1007/s10528-025-11058-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Influence of FPGS rs1544105 and GGH rs3758149 Gene Polymorphisms on Methotrexate Pharmacogenetics.

Biochemical genetics - 1 Feb 2026

Giletti Andrea, Lorenzelli Franca, Menafra María Paz, Rivero Florencia, Lorenzo Mariana, Esperón Patricia

Abstract excerpt

Methotrexate (MTX) pharmacogenetics has been extensively investigated due to the high inter-individual variability in response to treatment. This wide variability can lead to treatment discontinuation or even death. Several genes involved in the pharmacodynamics and pharmacokinetics of MTX have been studied. However, there are still no guidelines for pharmacogenetics-guided MTX dosing. The FPGS rs1544105 and GGH...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Hematologic Neoplasms

Share to Hydroxymethyl and Formyl Transferases

Share to Methotrexate

Share to Multienzyme Complexes

Share to Pharmacogenetics

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 40050537
DOI: 10.1007/s10528-025-11058-7

Genes

FPGS
GGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of FPGS rs1544105 and GGH rs3758149 Gene Polymorphisms on Methotrexate Pharmacogenetics.PMID 40050537Read ↗

Effect of polymorphisms within methotrexate pathway genes on methotrexate toxicity and plasma levels in adults with hematological malignancies.Semantic proximity Read ↗

Methotrexate pharmacogenetics in Uruguayan adults with hematological malignant diseases.Semantic proximity Read ↗

The pharmacogenetics of methotrexateSemantic proximity Read ↗

Association of folylpolyglutamate synthase polymorphisms with methotrexate response and toxicity in rheumatoid arthritis: a meta-analysis.Semantic proximity Read ↗

Associations between the C677T and A1298C polymorphisms of MTHFR and the toxicity of methotrexate in childhood malignancies: a meta-analysis.Semantic proximity Read ↗

MTX pathway gene variants, erythrocyte methotrexate polyglutamates, and treatment outcomes in rheumatoid arthritis.Semantic proximity Read ↗

Methotrexate pharmacogenetics in rheumatoid arthritis: a status report.Semantic proximity Read ↗

Methotrexate-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses.Semantic proximity Read ↗

The impact of gene polymorphisms on the response of methotrexate-based treatments.Semantic proximity Read ↗

Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis.Semantic proximity Read ↗

Pharmacogenetics of methotrexateSemantic proximity Read ↗

Polymorphisms in Methotrexate Pathways: What Is Clinically Relevant, What Is Not, and What Is PromisingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.