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Article

Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia.

Pharmacogenetics and genomics - 1 Aug 2014

Zgheib Nathalie K, Akra-Ismail Maya, Aridi Carol, Mahfouz Rami, Abboud Miguel R, Solh Hassan, Muwakkit Samar A

Abstract excerpt

BACKGROUND: The aim of this study is to analyze polymorphisms in genes involved in 6-mercaptopurine detoxification (TPMT); methotrexate (MTX) metabolism including ABCB1 (or MDR1), ABCC2, SLC19A1 (or RFC1), and SLCO1B1; and the MTX effect mainly MTHFR and TYMS, and to assess whether these polymorphisms are predictors of treatment toxicity and/or MTX clearance. MATERIALS AND METHODS: This study included 127...

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Source

Identifiers

PMID: 25007187
DOI: 10.1097/FPC.0000000000000069

Genes

ABCB1
ABCC2
MTHFR
TYMS
RFC1
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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