[Influence of Methylenetetrahydrofolate Reductase C677T Polymorphism on High-Dose Methotrexate Toxicity in Pediatric Mature B-cell lymphoma Patients].

doi:10.19746/j.cnki.issn.1009-2137.2024.06.015

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[Influence of Methylenetetrahydrofolate Reductase C677T Polymorphism on High-Dose Methotrexate Toxicity in Pediatric Mature B-cell lymphoma Patients].

Zhongguo shi yan xue ye xue za zhi - 1 Dec 2024

Xu Jia-Qian, Wang Juan, Lu Su-Ying, Wu Yan-Peng, Guo Lan-Ying, Shi Bo-Yu, Sun Fei-Fei, Huang Jun-Ting, Zhu Jia, Zhen Zi-Jun, Sun Xiao-Fei, Zhang Yi-Zhuo

Abstract excerpt

OBJECTIVE: To investigate the effect of genetic polymorphism of MTHFR C677T (rs1801133) on methotrexate (MTX) related toxicity in pediatric mature B-cell lymphoma patients. METHODS: Fifty-eight intermediate and high risk patients under 18 years of age with mature B-cell lymphoma who received 5 g/m 2 MTX (24 h intravenous infusion) in Sun Yat-sen University Cancer Center from August 2014 to December 2021 were...

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PMID: 39743258
DOI: 10.19746/j.cnki.issn.1009-2137.2024.06.015

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