<scp>PTEN</scp> controls β‐cell regeneration in aged mice by regulating cell cycle inhibitor p16 ^<i>ink4a</i>

Abstract excerpt

Tissue regeneration diminishes with age, concurrent with declining hormone levels including growth factors such as insulin-like growth factor-1 (IGF-1). We investigated the molecular basis for such decline in pancreatic β-cells where loss of proliferation occurs early in age and is proposed to contribute to the pathogenesis of diabetes. We studied the regeneration capacity of β-cells in mouse model where PI3K/AKT...

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