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Article

The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells

20 Jul 2018

Abstract excerpt

Skeletal muscle stem cell (MuSC) function declines with age and contributes to impaired muscle regeneration in older individuals. Acting through AMPK/p27 Kip1 , we have identified a pathway regulating the balance between autophagy, apoptosis, and senescence in aged MuSCs. While p27 Kip1 is implicated in MuSC aging, its precise role and molecular mechanism have not been elucidated. Age-related MuSC dysfunction was...

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PMID: 30033086
DOI: 10.1016/j.stemcr.2018.06.014

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