Too many breaks (brakes): Pancreatic β-cell senescence leads to diabetes

Abstract excerpt

Pancreatic β-cells regulate glucose homeostasis by secreting insulin in response to metabolic demands. The generation of these adult endocrine cells predominantly occurs through self-replication rather than through differentiation from their stem-cell progenitors; therefore, regulating cellular division through the cell cycle machinery is an essential component of this process. Arrest of the pancreatic β-cell...

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