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Article

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication

2 Mar 2016

Abstract excerpt

Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however, pharmacological agents that promote regeneration or expansion of endogenous β-cells have been elusive. The regenerative capacity of β-cells declines rapidly with age,...

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PMID: 26936960
DOI: 10.2337/db15-1331

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