Article
Mutational analysis of hedgehog signaling pathway genes in human malignant mesothelioma.
PloS one - 1 Jan 2013
Lim Chuan Bian, Prêle Cecilia M, Cheah Hui Min, Cheng Yuen Yee, Klebe Sonja, Reid Glen, Watkins D Neil, Baltic Svetlana, Thompson Philip J, Mutsaers Steven E
Abstract excerpt
BACKGROUND: The Hedgehog (HH) signaling pathway is critical for embryonic development and adult homeostasis. Recent studies have identified regulatory roles for this pathway in certain cancers with mutations in the HH pathway genes. The extent to which mutations of the HH pathway genes are involved in the pathogenesis of malignant mesothelioma (MMe) is unknown. METHODOLOGY/PRINCIPAL FINDINGS: Real-time PCR...
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