Article
Genetic landscape and ligand-dependent activation of sonic hedgehog-Gli1 signaling in chordomas: a novel therapeutic target.
Oncogene - 1 Jun 2020
Yang Chenlong, Yong Lei, Liang Chen, Li Yan, Ma Yunlong, Wei Feng, Jiang Liang, Zhou Hua, He Guanping, Pan Xiaoyu, Hai Bao, Wu Jian, Xu Yulun, Liu Zhongjun, Liu Xiaoguang
Abstract excerpt
Chordoma, a rare neoplasm derived from intraosseous notochordal remnants, is unresponsive to conventional chemotherapy and radiotherapy. Sonic Hedgehog (Shh) is a crucial fetal notochord-secreted morphogen that directs notochordal development. The aim of this study was to determine the functional roles and therapeutic potential of Shh-Gli1 signaling in chordomas. Tissue samples and clinical profiles were...
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