Article
Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.
Oncotarget - 29 Nov 2016
Tang Chih-Min, Lee Tracy E, Syed Sabriya A, Burgoyne Adam M, Leonard Stephanie Y, Gao Fei, Chan Jonathan C, Shi Eileen, Chmielecki Juliann, Morosini Deborah, Wang Kai, Ross Jeffrey S, Kendrick Michael L, Bardsley Michael R, Siena Martina De, Mao Junhao, Harismendy Olivier, Ordog Tamas, Sicklick Jason K
Abstract excerpt
Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of gastrointestinal mesenchymal development. Therefore, we hypothesized that Hedgehog signaling may be altered in human GIST and controls KIT expression. Quantitative RT-PCR,...
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