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Article

Mutations in the hedgehog pathway genes SMO and PTCH1 in human gastric tumors.

PloS one - 1 Jan 2013

Wang Xi-De, Inzunza Hector, Chang Han, Qi Zhenhao, Hu Beihong, Malone Daniel, Cogswell John

Abstract excerpt

The causal role of the hedgehog pathway in cancer has been best documented in basal cell carcinoma of the skin. To assess potential DNA alterations of the hedgehog pathway in gastric cancer, we sequenced SMO and PTCH1 genes in a set of 39 gastric tumors. Tumors were classified by histology based on the Lauren classification and Sanger sequencing was performed to obtain full length coding sequences. Genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23349881
DOI: 10.1371/journal.pone.0054415
PMCID: PMC3548780

Genes

PTCH1
SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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