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Article

Gene Expression Profiling of the Hedgehog Signaling Pathway in Human Meningiomas

26 Mar 2010

Abstract excerpt

The Hedgehog (Hh) signaling pathway has an important role during embryogenesis and in adult life, regulating proliferation, angiogenesis, matrix remodeling and stem-cell renewal. Deregulation of the Hh pathway is involved in tumor development, since mutations in several components of this pathway were found in patients with basal cell carcinoma, medulloblastoma and other tumors; however, the role of Hh in...

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PMID: 20386868
DOI: 10.2119/molmed.2010.00005

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