Article
Transcriptional infidelity promotes heritable phenotypic change in a bistable gene network.
PLoS biology - 24 Feb 2009
Gordon Alasdair J E, Halliday Jennifer A, Blankschien Matthew D, Burns Philip A, Yatagai Fumio, Herman Christophe
Abstract excerpt
Bistable epigenetic switches are fundamental for cell fate determination in unicellular and multicellular organisms. Regulatory proteins associated with bistable switches are often present in low numbers and subject to molecular noise. It is becoming clear that noise in gene expression can influence cell fate. Although the origins and consequences of noise have been studied, the stochastic and transient nature of...
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