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DosR antigen Rv1737c induces activation of macrophages dependent on the TLR2 pathway

28 Jun 2019

Abstract excerpt

Latent Mycobacterium tuberculosis (Mtb) infection (LTBI) is the main clinical manifestation after Mtb exposure. During the latent phase, Mtb retards the attempts of eradication by the host immune system. The dormancy survival regulator (DosR) is held as essential for Mtb persistence. Rv1737c is predominantly expressed by the Mtb in latent infection. However, the role of Rv1737c in the immune evasion is still...

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PMID: 31326120
DOI: 10.1016/j.cellimm.2019.103947

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