Mycobacterium tuberculosis DosR Regulon Gene Rv2004c Encodes a Novel Antigen with Pro-inflammatory Functions and Potential Diagnostic Application for Detection of Latent Tuberculosis

Abstract excerpt

Approximately 1.7 billion population of the world contain latent Mycobacterium tuberculosis (Mtb) with a substantial risk of progression to clinical outcome. Containment of seed beds of Mtb is essential to eliminate tuberculosis completely in high burden settings like India. Hence, there is an urgent need for the development of putative serological markers for detection or vaccine candidates to prevent latent...

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