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Novel In Silico mRNA vaccine design exploiting proteins of M. tuberculosis that modulates host immune responses by inducing epigenetic modifications

17 Mar 2022

Abstract excerpt

Tuberculosis is an airborne infectious disease caused by Mycobacterium tuberculosis. BCG is the only approved vaccine. However, it has limited global efficacy. Pathogens could affect the transcription of host genes, especially the ones related to the immune system, by inducing epigenetic modifications. Many proteins of M. tuberculosis were found to affect the host's epigenome. Nine proteins were exploited in this...

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RNA and protein synthesis mechanisms
Tuberculosis Research and Epidemiology
vaccines and immunoinformatics approaches

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35301360
DOI: 10.1038/s41598-022-08506-4

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