Article
Genetic determinants of plasma total homocysteine.
Seminars in vascular medicine - 1 May 2005
Gellekink Henkjan, den Heijer Martin, Heil Sandra G, Blom Henk J
Abstract excerpt
Hyperhomocysteinemia (Hhcy) is an established risk factor for various pathologies including arterial vascular disease and venous thrombosis, congenital malformations and other pregnancy complications, and dementia. Homocysteine remethylation, transsulfuration, and export to the blood/extracellular compartment determine homocysteine concentrations. Any disturbance in these routes may lead to Hhcy and potentially...
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