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Article

Alkaline pH block of CLC-K kidney chloride channels mediated by a pore lysine residue.

Biophysical journal - 2 Jul 2013

Gradogna Antonella, Pusch Michael

Abstract excerpt

CLC-K chloride channels are expressed in the kidney and the inner ear, where they are involved in NaCl reabsorption and endolymph production, respectively. These channels require the beta subunit barttin for proper function. Mutations in ClC-Kb and barttin, lead to Bartter's syndrome. Block of CLC-K channels by acid pH was described in a previous work, and we had identified His-497 as being responsible for the...

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Identifiers

PMID: 23823226
DOI: 10.1016/j.bpj.2013.05.044
PMCID: PMC3699751

Genes

CLC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alkaline pH block of CLC-K kidney chloride channels mediated by a pore lysine residue.PMID 23823226Read ↗

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