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Article

Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2005

Hawn Thomas R, Verbon Annelies, Janer Marta, Zhao Lue Ping, Beutler Bruce, Aderem Alan

Abstract excerpt

The immunogenetic factors that influence susceptibility to pneumonia are poorly understood. Recent studies suggest an association of toll-like receptor 4 (TLR4) polymorphisms with increased susceptibility to some infections. Here, we examined whether polymorphisms in TLR4 influence susceptibility to Legionnaires' disease (LD) by using a case-control study to compare the allele frequencies of two SNPs (A896G and...

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Identifiers

PMID: 15699327
DOI: 10.1073/pnas.0409831102
PMCID: PMC549026

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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