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Article

GWIS--model-free, fast and exhaustive search for epistatic interactions in case-control GWAS.

BMC genomics - 1 Jan 2013

Goudey Benjamin, Rawlinson David, Wang Qiao, Shi Fan, Ferra Herman, Campbell Richard M, Stern Linda, Inouye Michael T, Ong Cheng Soon, Kowalczyk Adam

Abstract excerpt

BACKGROUND: It has been hypothesized that multivariate analysis and systematic detection of epistatic interactions between explanatory genotyping variables may help resolve the problem of "missing heritability" currently observed in genome-wide association studies (GWAS). However, even the simplest bivariate analysis is still held back by significant statistical and computational challenges that are often...

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PMID: 23819779
DOI: 10.1186/1471-2164-14-S3-S10
PMCID: PMC3665501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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