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Article

Germline Genetic Variants in the Wnt/β-Catenin Pathway as Predictors of Colorectal Cancer Risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2016

Hildebrandt Michelle A T, Reyes Monica E, Lin Moubin, He Yonggang, Nguyen Son V, Hawk Ernest T, Wu Xifeng

Abstract excerpt

BACKGROUND: The Wnt/β-catenin signaling pathway plays a key role in stem cell maintenance in the colorectum. Rare high-penetrance genetic mutations in components of this pathway result in familial colorectal cancer, yet the impact of common, germline variants remains unknown. METHODS: We assessed 172 variants in 26 genes from the Wnt/β-catenin pathway in 809 colorectal cancer cases and 814 healthy controls,...

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Identifiers

PMID: 26809274
DOI: 10.1158/1055-9965.EPI-15-0834
PMCID: PMC4779688

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APC
FZD3
IMPACT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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