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Article

A functional germline variant in GLI1 implicates hedgehog signaling in clinical outcome of stage II and III colon carcinoma patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2014

Szkandera Joanna, Pichler Martin, Absenger Gudrun, Stotz Michael, Weissmueller Melanie, Samonigg Hellmut, Asslaber Martin, Lax Sigurd, Leitner Gerhard, Winder Thomas, Renner Wilfried, Gerger Armin

Abstract excerpt

PURPOSE: Cumulating evidence indicates that germline variants in the Wnt, Notch, and Hedgehog pathways are involved in colon carcinoma progression and metastasis. We investigated germline polymorphisms in a comprehensive panel of Wnt, Notch, and Hedgehog pathway genes to predict time to recurrenc...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24470513
DOI: 10.1158/1078-0432.CCR-13-1517

Genes

GLI1
TTR
APC
AXIN2
MYC
NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24470513-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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