Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data.

doi:10.1016/j.jbiosc.2013.05.021

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Article

Identification of a candidate single-nucleotide polymorphism related to chemotherapeutic response through a combination of knowledge-based algorithm and hypothesis-free genomic data.

Journal of bioscience and bioengineering - 1 Dec 2013

Takahashi Hiro, Kaniwa Nahoko, Saito Yoshiro, Sai Kimie, Hamaguchi Tetsuya, Shirao Kuniaki, Shimada Yasuhiro, Matsumura Yasuhiro, Ohtsu Atsushi, Yoshino Takayuki, Takahashi Anna, Odaka Yoko, Okuyama Misuzu, Sawada Jun-ichi, Sakamoto Hiromi, Yoshida Teruhiko

Abstract excerpt

Inter-individual variations in drug responses among patients are known to cause serious problems in medicine. Genome-wide association study (GWAS) is powerful for examining single-nucleotide polymorphisms (SNPs) and their relationships with drug response variations. However, no significant SNP has been identified using GWAS due to multiple testing problems. Therefore, we propose a combination method consisting of...

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PMID: 23816762
DOI: 10.1016/j.jbiosc.2013.05.021

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