Article
Application of a combination of a knowledge-based algorithm and 2-stage screening to hypothesis-free genomic data on irinotecan-treated patients for identification of a candidate single nucleotide polymorphism related to an adverse effect.
PloS one - 1 Jan 2014
Takahashi Hiro, Sai Kimie, Saito Yoshiro, Kaniwa Nahoko, Matsumura Yasuhiro, Hamaguchi Tetsuya, Shimada Yasuhiro, Ohtsu Atsushi, Yoshino Takayuki, Doi Toshihiko, Okuda Haruhiro, Ichinohe Risa, Takahashi Anna, Doi Ayano, Odaka Yoko, Okuyama Misuzu, Saijo Nagahiro, Sawada Jun-ichi, Sakamoto Hiromi, Yoshida Teruhiko
Abstract excerpt
Interindividual variation in a drug response among patients is known to cause serious problems in medicine. Genomic information has been proposed as the basis for "personalized" health care. The genome-wide association study (GWAS) is a powerful technique for examining single nucleotide polymorphisms (SNPs) and their relationship with drug response variation; however, when using only GWAS, it often happens that...
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