Article
Polymorphism discovery in 51 chemotherapy pathway genes.
Human molecular genetics - 1 Dec 2005
Freimuth Robert R, Xiao Ming, Marsh Sharon, Minton Matthew, Addleman Nicholas, Van Booven Derek J, McLeod Howard L, Kwok Pui-Yan
Abstract excerpt
Candidate gene pharmacogenetic studies offer a strategy for the rapid assessment of putative predictive markers. As a first step toward studying the pharmacogenetics of cancer chemotherapy, 51 candidate genes from the pathways of antineoplastic agents were resequenced to identify common genetic polymorphisms that might alter therapeutic response or toxicity. Forty DNA samples were screened from each of three...
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