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Article

Identification of 2-piperidone as a biomarker of CYP2E1 activity through metabolomic phenotyping.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Sept 2013

Cheng Jie, Chen Chi, Kristopher Krausz W, Manna Soumen K, Scerba Mike, Friedman Fred K, Luecke Hans, Idle Jeffrey R, Gonzalez Frank J

Abstract excerpt

Cytochrome P450 2E1 (CYP2E1) is a key enzyme in the metabolic activation of many low molecular weight toxicants and also an important contributor to oxidative stress. A noninvasive method to monitor CYP2E1 activity in vivo would be of great value for studying the role of CYP2E1 in chemical-induced toxicities and stress-related diseases. In this study, a mass spectrometry-based metabolomic approach was used to...

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Identifiers

PMID: 23811823
DOI: 10.1093/toxsci/kft143
PMCID: PMC3748767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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