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Epigenetic Regulation of Drug Metabolism in Aging: Utilizing Epigenetics to Optimize Geriatric Pharmacotherapy

21 Dec 2023

Abstract excerpt

We explore the relationship between epigenetic aging and drug metabolism. We review current evidence for changes in drug metabolism in normal aging, followed by a description of how epigenetic modifications associated with age can regulate the expression and functionality of genes. In particular, we focus on the role of epigenome-wide studies of human and mouse liver in understanding these age-related processes...

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PMID: 38126340
DOI: 10.2217/pgs-2023-0199

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