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Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics

3 Feb 2015

Abstract excerpt

Primaquine (PQ) metabolism by the cytochrome P450 (CYP) 2D family of enzymes is required for antimalarial activity in both humans (2D6) and mice (2D). Human CYP 2D6 is highly polymorphic, and decreased CYP 2D6 enzyme activity has been linked to decreased PQ antimalarial activity. Despite the importance of CYP 2D metabolism in PQ efficacy, the exact role that these enzymes play in PQ metabolism and...

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PMID: 25645856
DOI: 10.1128/aac.00015-15

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