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Article

The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer.

BMC gastroenterology - 28 Feb 2022

Lei Ruixue, Zhao Yanteng, Huang Kai, Wang Qian, Wan Kangkang, Li Tingting, Yang Haijun, Lv Xianping

Abstract excerpt

BACKGROUND: Methylated SDC2 and TFPI2 are widely used for colorectal cancer (CRC) detection. However, they often miss some CRCs, which directly diminishes the sensitivity. Further investigations of the underlying mechanisms leading to the missed samples will facilitate developing more eligible methylation markers. METHODS: CRC samples from TCGA and GEO datasets were divided into three groups, High-methylation/...

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Identifiers

PMID: 35227195
DOI: 10.1186/s12876-022-02175-3
PMCID: PMC8886827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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