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Article

ATP citrate lyase knockdown impacts cancer stem cells in vitro

27 Jun 2013

Abstract excerpt

ATP citrate lyase (ACL) knockdown (KD) causes tumor suppression and induces differentiation. We have previously reported that ACL KD reverses epithelial-mesenchymal transition (EMT) in lung cancer cells. Because EMT is often associated with processes that induce stemness, we hypothesized that ACL KD impacts cancer stem cells. By assessing tumorsphere formation and expression of stem cell markers, we showed this...

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PMID: 23807225
DOI: 10.1038/cddis.2013.215

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