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Article

β-hydroxybutyrate, a ketone body, suppresses tumor growth, stemness, and invasive phenotypes in non-small cell lung cancer.

Cancer biology & therapy - 1 Dec 2025

Huang Yunlong, Ding Jiaxuan, Zhu Yufeng, Shi Jin, Liu Rong, Wu Chunmei, Han Liangfu, Zhang Mingfeng

Abstract excerpt

Lung cancer is the most common cancer worldwide. The stemness and metastasis of tumor cells present major challenges to effective lung cancer treatment. Beta-hydroxybutyrate (BHB), a ketone body, plays a key role in various cancers. However, whether BHB mediates the progression of non-small cell lung cancer (NSCLC) remains unclear. The effects of BHB on the proliferation, apoptosis, and metastasis of NSCLC cells...

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Identifiers

PMID: 40545696
DOI: 10.1080/15384047.2025.2516825
PMCID: PMC12919899

Genes

FFAR3
PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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