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Article

Suppression of a cancer stem-like phenotype mediated by alpha-lipoic acid in human lung cancer cells through down-regulation of β-catenin and Oct-4.

Cellular oncology (Dordrecht, Netherlands) - 1 Oct 2017

Phiboonchaiyanan Preeyaporn Plaimee, Chanvorachote Pithi

Abstract excerpt

PURPOSE: Cancer stem cells (CSCs) that possess the ability of self-renewal and multi-potency have been shown to drive tumor progression and metastasis. The majority of recent studies has focused on potential molecules targeting CSCs so as to develop novel strategies for efficient cancer treatment or protection. Here, we show how alpha-lipoic acid (LA), an endogenous mitochondrial anti-oxidant, affects the...

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Source

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Identifiers

PMID: 28677037
DOI: 10.1007/s13402-017-0339-3
PMCID: PMC13001574

Genes

ALDH1A1
CD44

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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