Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma.

doi:10.1016/j.jhep.2020.12.031

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Article

Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma.

Journal of hepatology - 1 Jun 2021

Raggi Chiara, Taddei Maria Letizia, Sacco Elena, Navari Nadia, Correnti Margherita, Piombanti Benedetta, Pastore Mirella, Campani Claudia, Pranzini Erica, Iorio Jessica, Lori Giulia, Lottini Tiziano, Peano Clelia, Cibella Javier, Lewinska Monika, Andersen Jesper B, di Tommaso Luca, Viganò Luca, Di Maira Giovanni, Madiai Stefania, Ramazzotti Matteo, Orlandi Ivan, Arcangeli Annarosa, Chiarugi Paola, Marra Fabio

Abstract excerpt

BACKGROUND & AIMS: Little is known about the metabolic regulation of cancer stem cells (CSCs) in cholangiocarcinoma (CCA). We analyzed whether mitochondrial-dependent metabolism and related signaling pathways contribute to stemness in CCA. METHODS: The stem-like subset was enriched by sphere culture (SPH) in human intrahepatic CCA cells (HUCCT1 and CCLP1) and compared to cells cultured in monolayer. Extracellular...

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PMID: 33484774
DOI: 10.1016/j.jhep.2020.12.031

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