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Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells

27 Jun 2013

Abstract excerpt

The histone methyltransferase G9a is overexpressed in a variety of cancer types, including pancreatic adenocarcinoma, and promotes tumor invasiveness and metastasis. We recently reported the discovery of BRD4770, a small-molecule inhibitor of G9a that induces senescence in PANC-1 cells. We observed that the cytotoxic effects of BRD4770 were dependent on genetic background, with cell lines lacking functional p53...

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PMID: 23807219
DOI: 10.1038/cddis.2013.191

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