Article

BCN057, a Modulator of GSK3β, Induces KRAS G12D Mutant Pancreatic Cancer Cell Death

2021-09-04

Abstract excerpt

Effective treatment for Pancreatic Cancer remains a major challenge due to its resistance to radiation/chemotherapy and poor drug permeability. Moreover, treatment induced normal tissue toxicity, mainly to the duodenum and gastrointestinal epithelium, is common and is a dose limiting event, while toxicity to the pancreas is relatively rare 1–3 . Gastrointestinal toxicity, however, often results in interruption, r...

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Literature Corpus work: 62d35f79-b576-5649-844e-bd120e9bbd73
DOI: 10.1101/2021.09.03.458938

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