Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway

11 Dec 2015

Abstract excerpt

PURPOSE: Recent studies suggest that SIRT1-activating compounds (STAC) are a promising class of anticancer drugs, although their mechanism of action remains elusive. The main goal of this study is to determine the role of STACs as a potential therapy for pancreatic cancer. In addition, we also explored the mechanism by which these compounds affect pancreatic cancer. EXPERIMENTAL DESIGN: Using in vitro (cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium signaling and nucleotide metabolism
Share to PARP inhibition in cancer therapy
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26655844
DOI: 10.1158/1078-0432.ccr-15-1760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent PathwayPMID 26655844Read ↗

SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cellsSemantic proximity Read ↗

SRT1720 Induces Lysosomal-Dependent Cell Death of Breast Cancer CellsSemantic proximity Read ↗

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.Semantic proximity Read ↗

SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatmentSemantic proximity Read ↗

Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer.Semantic proximity Read ↗

BCN057, a Modulator of GSK3β, Induces KRAS G12D Mutant Pancreatic Cancer Cell DeathSemantic proximity Read ↗

Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathwaySemantic proximity Read ↗

A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastomaSemantic proximity Read ↗

Scoparone induces autophagic cell death via the PAK1/AKT axis in colorectal cancerSemantic proximity Read ↗

Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drugSemantic proximity Read ↗

L-Ascorbic acid preferentially kills KRAS mutant pancreatic cancer cells through DNA damageSemantic proximity Read ↗

Autophagy in pancreatic cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.