Article

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Enhances the Antitumoral Activity of Gemcitabine in Human Pancreatic Cancer Cell Lines

2014-01-01

Abstract excerpt

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most common malignant tumors still associated with poor prognosis in advanced stages. Gemcitabine is one of the standard agents for the treatment of PDAC, without having a major impact on the clinical outcome. Combining two compounds acting via different ways of action may result in a better efficacy. Methods: We investigated the effects of gemc...

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Identifiers and source

Literature Corpus work: 39fa242e-a23c-58a6-8885-158211c6798c
DOI: 10.4172/2329-6771.1000133

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